How to apply Frontline: Hold the pipette upright. Tap the narrow part of the pipette to ensure that the contents are within the main body of the pipette. Break the snap-off top along the scored line. Part the fur between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently to empty the contents onto the skin at two spots: one at the base of the skull and one 2-3cm further back. It is important to make sure the product is applied to an area where the cat cannot lick the product off. Once applied, Frontline Combo will last up to 4 weeks. It is recommended to not bathe your cat within 2 days of applying Frontline. Do not use on sick or convalescent animals. Do not use in rabbits.